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Download Activating and Inhibitory Immunoglobulin-like Receptors by Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki PDF

By Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)

A notable spectrum of novel immunoreceptors sharing similar immunoglobulin-like domain names and signaling strength has been pointed out lately. those receptors have attracted common curiosity simply because they resemble the TCR, BCR, and FcR complexes of their skill to function activating or inhibitory receptors at the cells that endure them. in addition, they're good situated to impact either innate and adaptive immunity. the whole diversity of ligands for those new receptor households continues to be now not identified, and knowing in their physiological roles is way from whole. This quantity is the 1st try and summarize and spotlight all identified points of immunoglobulin-like receptors, supplying a topical evaluation of the jobs and attribute beneficial properties of the immunoglobulin-like receptors and comparable molecules within the immune procedure. Researchers in immunology, molecular biology, cellphone biology, medical drugs, and pharmacology will locate this publication invaluable.

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1999), and they are expressed as disulfide-linked dimers with type II integral 25 26 membrane topology . Mouse NK cells recognize MHC class I with inhibitory Ly49 and CD94INKG2A receptors (Yokoyama 1998). The specificity of human NK cells is endowed not only by CD94/NKG2 receptors but also by killer inhibitory receptors (KIR), type I membrane proteins belonging to the Ig superfamily, which bind to specific HLA class I molecules (Long 1999). Despite their opposing membrane orientations, the inhibitory receptors mediate their effect s through a conserved signaling mechanism : Recruitment of the SHP-I tyrosine phosphatase to phosphorylated receptor immunoreceptor tyrosine-based inhibitory motifs OTIMs) .

Lopez-Botet M (1999) A novel family of lg-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J Leukoc BioI 66 :375-381 Dor fman JR, Raulet DH (1998) Acqu isition of Ly49 receptor expre ssion by developing natural kilIer cell s. J Exp Med 187:609-6 18 Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inui M. Ohyama Y. Hikida M, Ohmori H. Takai T ( 1997) Molecul ar cloning of a novel murine cell -surface glycoprotein homologous to killer cell inh ibitor y receptors.

In mice treated with poly-LC, an inducer of type I interferons, gp49 expression by NK cells is also induced (data not shown). Based on our in vitro observation that stimulation of mature NK cells induces gp49 , the enhanced expression of gp49 following MCMV infection strongly suggest that gp49 expression is induced upon physiological stimuli and 29 that the role of these receptors is to modulate NK cell activity some time after initial activation . Thus, it is not surprising that NK cell development is normal in mice with targeted deficiency in gp49B but these mice may manifest abnormalities in innate defense as suggested by our studies and those of the Long group (Rojo et al.

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