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Download Chorionic Gonadotropin by Roy Hertz (auth.), Sheldon J. Segal (eds.) PDF

By Roy Hertz (auth.), Sheldon J. Segal (eds.)

This quantity is dedicated to the chemistry, immunology, molecular biology, and body structure of the human chorionic gonadotropin, heG. For this glycoprotein molecule the direction from discovery to chemical interpreting coated approximately fifty years. It used to be in 1928 that Ascheim and Zondek mentioned that urine from pregnant girls includes whatever that stimulates the ovaries of mice or rats. This supplied the foundation for the recognized A-Z try for being pregnant and for the "rabbit attempt" amendment brought through Friedman. As researchers sought to discover extra delicate responses to heG, they used a large choice of species together with the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South the US, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather response used to be quite noteworthy, for it disclosed a non-gonadal reaction to heG/LH. looking back, this can were a massive evolutionary clue to the conclusion that the designation of the hormone as a "gonadotropin" can have been simply in part descriptive of the molecule's physiological function--a idea that is gaining consciousness, because the papers during this 1980 quantity divulge.

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I ·1 . 1 0. 8 0. 0 Kov Figure 3. 5 placentae, chromatographed on Sephadex G-200. Each fraction was assayed in hCG, hCGa, and hCGS RIA. The position for human serum albumin (HSA) is indicated . (From Wide and Hobson, 1978 . ) material to be tested was mixed with 125I-labeled hCG and serum from a child (without detectable hCG activity). After electrophoresis, 1 cm fractions were collected , the agarose removed by centrifugation, and the CG activity in the supernatants was measured. The mobility of purified hCG (CR-119 ) and of hCG in pregnancy urine (first trimester) were very similar to 125I-labeled hCG (Figure 6).

Bell, J. , and Agosto, G. , 1971, Studies on human chorionic gonadotropin, Recent Progr. Horm. Res. 27:121. Canfield, R. , and Ross, G. , 1976, A new reference preparation of human chorionic gonadotropin and its subunits, Bull. WHO 54:463. , 1979, The interaction of radioiodinated TSH with human plasma membranes from normal and diseased thyroid glands, Ann. Endocrinol. (Paris) 40:211. Davies, T. , and Nisula, B. , 1979, Assessment of urinary TSH-competing activity in choriocarcinoma and thyroid disease: Further evidence for hCG interacting at the thyroid cell membrane, J.

Patients with levels of hCG exceeding those of pregnancy would be the logical ones to scrutinize. Figure 6 shows peripheral thyroid hormone levels in patients with gestational trophoblastic disease in whom the serum hCG level may be quite high. In the occasional patient, the serum hCG level can be many-fold greater than in normal pregnancy; and in such patients (Figure 6), accelerated thyroid function and symptomatic thyrotoxicosis are seen. , >100 IU/ml). These results are consistent with the hypothesis that the TSA intrinsic to the hCG molecule mediates the increased thyroid function seen in patients with gestational trophoblastic disease.

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